A analysis workforce from Université Laval has proven the advantages of camu-camu on non-alcoholic fatty liver illness, which impacts over seven million folks in Canada. This unique fruit reduces liver fats ranges.
Over 12 weeks, thirty contributors took both camu-camu extract or a placebo at totally different occasions on this randomized medical trial. Individuals underwent magnetic resonance imaging (MRI) to find out fats ranges within the liver. Scientists noticed a 7.43% discount in liver lipids when examine contributors took camu-camu extract. With the placebo, they famous an 8.42% enhance in liver fats.
“That is a big 15.85% distinction,” says André Marette, a professor within the School of Medication and researcher on the Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval (IUCPQ), who led the examine.
Polyphenols and the microbiota
This impact stems from the polyphenols contained in camu-camu and their relationship with the intestinal microbiota. “The microbiota metabolizes the massive polyphenol molecules that can not be absorbed by the gut, remodeling them into smaller molecules that the physique can assimilate to lower liver fats,” explains André Marette.
His workforce has recognized two potential mechanisms of motion for these small polyphenols. “They may cut back lipogenesis, i.e., the formation of lipid droplets within the liver. They may additionally stimulate lipid degradation by oxidation. A mix of the 2 mechanisms in all probability explains the excessive efficacy of the extract, as we’re taking part in on each side of the coin,” studies Professor Marette, who collaborated with scientists on the Institute of Diet and Useful Meals (INAF).
Nonetheless, the workforce famous a large variability in response to camu-camu.
We hypothesize that the preliminary intestinal microbiota influences the response to polyphenols. If we discover the elements concerned, we might be able to modify the microbiota and enhance the extract efficacy.”
André Marette, professor within the School of Medication and researcher on the Institut universitaire de cardiologie et de pneumologie de Québec – Université Laval
Though camu-camu is an unique fruit, the extract is available in capsule kind. Nonetheless, Professor Marette stresses the significance of checking the content material of sure polyphenols, as not all industrial merchandise are equal.
Cranberries, which additionally include plenty of partially totally different polyphenols, may even have a protecting impact. Sooner or later, Professor Marette hopes to research whether or not combining camu-camu and cranberry may have a synergistic impact.
The examine was printed within the journal Cell Reviews Medication. The opposite authors are Anne-Laure Agrinier, Arianne Morissette, Laurence Daoust, Théo Gignac, Julie Marois, Thibault V. Varin, Geneviève Pilon, Éric Larose, Claudia Gagnon, Yves Desjardins, Fernando F Anhê, Anne-Marie Carreau and Marie-Claude Vohl.
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Journal reference:
Agrinier, A-L., et al. (2024) Camu-camu decreases hepatic steatosis and liver harm markers in chubby, hypertriglyceridemic people: A randomized crossover trial. Cell Reviews Medication. doi.org/10.1016/j.xcrm.2024.101682.
